At a news conference here, Mr. Obama denounced remarks Mr. Wright made in a series of televised appearances over the last several days. In the appearances, Mr. Wright has suggested that the United States was attacked because it engaged in terrorism on other people and that the government was capable of having used the AIDS virus to commit genocide against minorities. His remarks also cast Louis Farrakhan, the leader of the Nation of Islam, in a positive light.

In tones sharply different from those Mr. Obama used on Monday, when he blamed the news media and his rivals for focusing on Mr. Wright, and far harsher than those he used in his speech on race in Philadelphia last month, Mr. Obama tried to cut all his ties to — and to discredit — Mr. Wright, the man who presided at Mr. Obama’s wedding and baptized his two daughters.

“His comments were not only divisive and destructive, but I believe that they end up giving comfort to those who prey on hate, and I believe that they do not portray accurately the perspective of the black church,” Mr. Obama said, his voice welling with anger. “They certainly don’t portray accurately my values and beliefs.”

One week before Democratic primaries in Indiana and North Carolina, contests that party officials are watching as they try to gauge whether Mr. Obama or Senator Hillary Rodham Clinton would be the stronger nominee, the controversy surrounding Mr. Wright again erupted into a threat to Mr. Obama’s ability to show that he could unify the Democratic Party and bring the nominating contest to a quick and clean end. With Mrs. Clinton having shown particular strength among working-class white voters in recent big-state primaries, the racial overtones of Mr. Obama’s links with Mr. Wright have been especially troublesome for the Obama campaign.

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